Ribosomes are essential cellular nanomachines, converting the genetic information encoded in messenger RNAs (mRNAs) into proteins playing structural or catalytic roles in the cell. The human ribosome contains four rRNAs and eighty ribosomal proteins ...

We are characterizing ribosome assembly pathways in human cells and budding yeast. We are particularly interested by RNA processing and RNA modification. Eukaryotic ribosome biogenesis is a complex process, which is initiated in the nucleolus, proceeds into the nucleoplasm and is finalized in the cytoplasm. All three RNA polymerases are ...

We are characterizing the principles of nucleolar structure integrity maintenance and dynamics. Ribosome synthesis is initiated in the nucleolus...

We are developing novel nucleolar cancer biomarkers for improved classification of malignancies and patient stratification. We are implementing animal models to study the effects of ribosome...

In collaboration with structural biologists, we are characterizing the 3-D structure of assembly factors involved in ribosome biogenesis.