Molecular, Cellular & Pathophysiological Aspects of Ribosome Biogenesis

Ribosomes are essential cellular nanomachines, converting the genetic information encoded in messenger RNAs (mRNAs) into proteins playing structural or catalytic roles in the cell. The human ribosome contains four rRNAs and eighty ribosomal proteins ...

Understanding Human Ribosome Biogenesis

We are characterizing ribosome assembly pathways in human cells and budding yeast. We are particularly interested by RNA processing and RNA modification. Eukaryotic ribosome biogenesis is a complex process, which is initiated in the nucleolus, proceeds into the nucleoplasm and is finalized in the cytoplasm. All three RNA polymerases are ...

Understanding Human Nucleolar Structure

We are characterizing the principles of nucleolar structure integrity maintenance and dynamics. Ribosome synthesis is initiated in the nucleolus...

Pathophysiological Aspects of Ribosome Biogenesis

We are developing novel nucleolar cancer biomarkers for improved classification of malignancies and patient stratification. We are implementing animal models to study the effects of ribosome...

Structural Approach to Ribosome Biogenesis

In collaboration with structural biologists, we are characterizing the 3-D structure of assembly factors involved in ribosome biogenesis.

A Collection of RNA Biology articles for Translacore

A Collection of RNA Biology articles for Translacore
TRANSLACORE, a European network to coordinate research on translation regulation in cancer “Translation at the Crossroads: A European Perspective on Protein Synthesis and Cancer” This...

Happy to co-organize RIBOMOD 2025 in Bologna

Happy to co-organize RIBOMOD 2025 in Bologna
For details, See https://events.unibo.it/ribomod2025

Translacore is networking scientists involved in translational control in cancer

Translacore is networking scientists involved in translational control in cancer
Translacore is a COST action (CA21154) aiming to develop a European network of excellence to foster basic research on mRNA translation in cancer. Translacore training...

Ribosome Fingerprints to help Cancer Diagnosis

Ribosome Fingerprints to help Cancer Diagnosis
In an amazing collaboration with the Eva Maria Novoa Lab (CRG, Barcelona, Spain), … Milenkovic et al. demonstrate that rRNA modifications are differentially modified across...

Diamond-Blackfan anemia @Global Bridges Madrid June 2024

Diamond-Blackfan anemia @Global Bridges Madrid June 2024
with friends Deena Iskander (Imperial College London, U.K.), Amee Georges (ANU, Canberra, Australia), Alan Warren (U Cambridge, U.K.), and Lorenzo Montanaro (U Bologna, Italy)

Detecting Material State Changes in Condensates with DHM

Detecting Material State Changes in Condensates with DHM
Digital Holographic Microscopy (DHM) was applied to detect membraneless biomolecular condensates and membrane-bound organelles without staining. The nucleolar optical thickness was defined for characterizing the...