Molecular, Cellular & Pathophysiological Aspects of Ribosome Biogenesis
Understanding Human Ribosome Biogenesis
Understanding Human Nucleolar Structure
Pathophysiological Aspects of Ribosome Biogenesis
Structural Approach to Ribosome Biogenesis
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RNA Spotlight – Thank you RNA Society!
https://www.rnasociety.org/prof-denis-l-j–lafontaine February 13, 2026 Written by: Dr. Anna Sherwood Edited by: Dr. Daniel L. Kiss Prof. Denis L.J. Lafontaine is a Research Director with the...
We’re hiring a PhD student – Starting date June 2026
PhD Position — The European Epitranscriptomics of Cancer Academy (EURECA) Network EURECA is a Marie Skłodowska-Curie Actions Doctoral Network (MSCA-DN) funded by the European Union....
What’s a Ribosome and What is it good for? Interview at LN24, November 2025
Thank you to Pascal Vrebos, journalist and interviewer, and to Stéphanie Tuetey of the F.R.S.–FNRS Communications Unit, for organizing the interview at the LN24 studio...
Happy to be part of EURECA! PhD positions available,… Apply now!
Exploring RNA modifications to revolutionise cancer care The European Epitranscriptomics of Cancer Academy (EURECA) Network is a Marie Skłodowska-Curie Actions Doctoral Network (MSCA-DN) funded by...
Turning the Nucleolus Upside Down and Engineering Synthetic Nucleoli in Cells
Together with the team of Cliff Brangwynne (Princeton) and Sebastian Klinge (Rockefeller), we have started to crack the blue print of the nucleolus. See Details...
A Collection of RNA Biology articles for Translacore
TRANSLACORE, a European network to coordinate research on translation regulation in cancer “Translation at the Crossroads: A European Perspective on Protein Synthesis and Cancer” This...
Happy to co-organize RIBOMOD 2025 in Bologna
For details, See https://events.unibo.it/ribomod2025 Full Program of RIBOMOD2025 Abstract Book of RIBOMOD2025 Initial Feedback to the Community – July 2025 The RNA Biology poster prize...
Translacore is networking scientists involved in translational control in cancer
Translacore is a COST action (CA21154) aiming to develop a European network of excellence to foster basic research on mRNA translation in cancer. Translacore training...
Ribosome Fingerprints to help Cancer Diagnosis
In an amazing collaboration with the Eva Maria Novoa Lab (CRG, Barcelona, Spain), … Milenkovic et al. demonstrate that rRNA modifications are differentially modified across...
Diamond-Blackfan anemia @Global Bridges Madrid June 2024
with friends Deena Iskander (Imperial College London, U.K.), Amee Georges (ANU, Canberra, Australia), Alan Warren (U Cambridge, U.K.), and Lorenzo Montanaro (U Bologna, Italy)
Detecting Material State Changes in Condensates with DHM
Digital Holographic Microscopy (DHM) was applied to detect membraneless biomolecular condensates and membrane-bound organelles without staining. The nucleolar optical thickness was defined for characterizing the...
RNA Society Meeting 2024. Thank you Edinburgh! May 28-June 2
Thank you to the organizers for their invitation as Session Chair Video recording of “RNA Modification” Session Introduction: with friends Tom Meier (Albert Einstein College...
China-UK Workshop on Molecular Haematopoiesis 2023: Thank you Tianjin!!
Thank you for an outstanding “China-UK Workshop on Molecular Haematopoiesis“ organized by my dear colleagues: Prof Tao CHENG, Prof Xiaofan ZHU, Prof Lihong SHI, and...
35th Tokyo RNA Club. November 2023. Happy to be back to Japan!
Thank you to my dear colleagues Prof. Tsustomu Suzuki and Prof. Tsuyoshi Osawa for their invitation.
Our long-term commitment to Diamond-Blackfan anemia
We are part of two European consortia: RiboEurope and DBAGeneCure aiming to understand the molecular basis and to develop therapeutics (gene therapy) for Diamond-Blackfan anemia...
Watch us @ Cold Spring Harbor Asia – Awaji Yumebutai, Japan 2022
Watch our Conference at CSHL Asia “RNA Biology 2022”, December 5-9, Awaji Yumebutai, Japan https://www.yumebutai.co.jp/lang/en.html
How ‘Nucleolar Surveillance’ is activated by Glutamine inside tumors
Nucleolar surveillance is a p53-dependent anti-tumoral pathway activated upon ribosome biogenesis dysfunction. It had remained unclear why liquid tumours respond better to ribosome biogenesis inhibitors...
EMBO RIBOSOME 2022, August 17-21, Engelberg
Co-organizers: Ute Kothe, Dieter Kressler, Denis Lafontaine, Tom Meier, Vikam Panse To Register, please visit the official EMBO website
Dihydrouridine on messenger RNAs slows ribosomes!
On the cover: In this issue of Molecular Cell, Finet et al. (pp. 404–419) use a transcriptome-wide approach to reveal that the dihydrouridine RNA modification (the...
Fibrillarin is required for Neural Crest Cell maturation
Ribosomes are essential nanomachines responsible for protein production in all cells. Ribosomopathies are diseases caused by improper ribosome formation due to mutations in ribosomal proteins...
The Nucleolus as a Multiphase Liquid Condensate
The nucleolus is the most prominent nuclear body and serves a fundamentally important biological role as a site of ribonucleoprotein particle assembly, primarily dedicated to...
The “iNo score”: Towards bringing the nucleolus in the clinics
Using the iNo score to discriminate normal from altered nucleolar morphology, with applications in basic cell biology and potential in human disease diagnostics ...
The 2018 International Meeting of the German Society for Cell Biology
The meeting took place in Leipzig, Germany, 17-19 September 2018 Invited speaker in the “Nuclear Dynamics & Communication” session.
The 11th International Ribosome Synthesis Meeting, Magog, Canada, August 1-5, 2018
The 11th International Ribosome Synthesis meeting will take place in Magog, Mont Orford, near Montreal, Canada form the 1-5 August 2018 at Manoir des Sables....
Curing cancer with Daffodils?
Pellegrino et al., have shown that haemanthamine inhibits both ribosome biogenesis and function, providing for the first time the molecular basis of the anticancer properties...
Involvement of U3 and U8 box C/D snoRNAs in tumorigenesis
Small nucleolar RNAs (snoRNAs) are emerging as a novel class of proto-oncogenes and tumor suppressors; their involvement in tumorigenesis remains unclear. The box C/D snoRNAs...
It’s a SPOUT! TSR3 the long sought 18S rRNA aminocarboxypropyl transferase
The chemically most complex modification in eukaryotic rRNA is the conserved hypermodified nucleotide N1-methyl-N3 aminocarboxypropyl pseudouridine (m¹acp³Ψ) located next to the P-site tRNA on the...
“Ki-67 organizes heterochromatin and is required for nucleolar genesis”
In Collaboration with Daniel Fisher (Montpellier Institute of Molecular Genetics – CNRS, Université de Montpellier), we showed that Ki-67 plays an important role during...
How targeting the long non-coding RNA SAMMSON may help kill melanoma cells
“Kill The Sammson, Kill The Melanoma” In a work led by Jean-Christophe Marine (VIB, KU Leuven) we contributed to the characterization of the lineage-specific long...
“View From A Bridge”: A New Perspective on Eukaryotic rRNA Base Modification
Eukaryotic rRNA are modified frequently, although the diversity of modifications is low: in yeast rRNA, there are only 12 different types out of a possible...
10th Ribosome Synthesis Meeting in Brussels, Belgium, 19-23 August 2015
Organizing committee: Sander GRANNEMAN (University of Edinburgh)Katrin KARBSTEIN (The SCRIPPS Research Institute, Florida)Denis LAFONTAINE (University of Brussels)Tom MEIER (Albert Einstein College of Medicine, New York)Joost...